Eastbound E Pender St @ Main St
| Time | Headsign |
| 09:09 | 22 Knight |
| 09:15 | 22 Knight to 63rd |
| 09:24 | 22 Knight |
| 09:33 | 22 Knight |
| 09:43 | 22 Knight |
| 09:58 | 22 Knight |
| 10:13 | 22 Knight |
| 10:28 | 22 Knight |
| 10:43 | 22 Knight |
| 10:58 | 22 Knight |
| 11:13 | 22 Knight |
| 11:28 | 22 Knight |
| 11:45 | 22 Knight |
| 12:00 | 22 Knight |
| 12:15 | 22 Knight |
| 12:30 | 22 Knight |
| 12:45 | 22 Knight |
| 13:00 | 22 Knight |
| 13:15 | 22 Knight |
| 13:30 | 22 Knight |
| 13:45 | 22 Knight |
| 14:00 | 22 Knight |
| 14:15 | 22 Knight |
| 14:30 | 22 Knight |
| 14:45 | 22 Knight |
| 15:00 | 22 Knight |
| 15:06 | 22 Knight via Industrial |
| 15:15 | 22 Knight |
| 15:29 | 22 Knight |
| 15:42 | 22 Knight |
| 15:53 | 22 Knight |
| 16:04 | 22 Knight |
| 16:14 | 22 Knight |
| 16:24 | 22 Knight to 63rd |
| 16:34 | 22 Knight |
| 16:44 | 22 Knight |
| 16:54 | 22 Knight |
| 17:05 | 22 Knight to 63rd |
| 17:15 | 22 Knight to 63rd |
| 17:25 | 22 Knight |
| 17:35 | 22 Knight |
| 17:45 | 22 Knight to 63rd |
| 17:55 | 22 Knight |
| 18:04 | 22 Knight to 63rd |
| 18:14 | 22 Knight |
| 18:25 | 22 Knight to 63rd |
| 18:37 | 22 Knight |
| 18:49 | 22 Knight |
| 19:04 | 22 Knight |
| 19:19 | 22 Knight |
| 19:34 | 22 Knight to 63rd |
| 19:49 | 22 Knight |
| 20:04 | 22 Knight |
| 20:19 | 22 Knight |
| 20:34 | 22 Knight |
| 20:49 | 22 Knight |
| 21:04 | 22 Knight |
| 21:19 | 22 Knight |
| 21:34 | 22 Knight |
| 21:49 | 22 Knight |
| 22:04 | 22 Knight |
| 22:18 | 22 Knight |
| 22:34 | 22 Knight |
| 22:48 | 22 Knight to 63rd |
| 23:03 | 22 Knight |
| 23:18 | 22 Knight to 63rd |
| 23:33 | 22 Knight |
| 23:48 | 22 Knight to 63rd |
| 00:07 | 22 Knight |
| 00:36 | 22 Knight |
| 01:06 | 22 Knight |
| These are the last 71 buses of the evening. |
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